منابع مشابه
Nuclear Hormone Receptors in T Lymphocytes
Among the numerous steroid and orphan nuclear receptors encoded within mammalian genomes, several are involved in regulating immune system functions. We review here recent studies on the glucocorticoid receptor and the orphan receptors Nur77 and RORgamma. These molecules play key roles in the development and the effector functions of T lymphocytes.
متن کاملReviewNuclear Hormone Receptors in T Lymphocytes
469 LSA tive selection) (Jameson et al., 1995). More than 95% of University of California, Berkeley immature double-positive (DP, CD4 CD8 ) thymocytes Berkeley, California 94720 undergo apoptosis. Most of these cells die by a process 2 Howard Hughes Medical Institute known as “death by neglect,” due to sub-threshold or Skirball Institute of Biomolecular Medicine absent interaction of the TCR wi...
متن کاملNuclear hormone receptors in C. elegans.
Nuclear receptors (NRs) are transcription factors typically regulated by lipophilic hormones, which coordinate metazoan metabolism, development and homeostasis. C. elegans has undergone a remarkable expansion of the family, harboring 284 of these receptors in its genome. Approximately 20 of them have been analyzed genetically, most of which correspond to conserved homologs in other metazoans. T...
متن کاملGene repression by nuclear hormone receptors.
Repression by nuclear hormone receptors (NHRs) plays an important role in development, immune response and cellular function. We review mechanisms of how NHRs act as repressors of gene transcription either by direct contact with basal transcription factors or through recruitment of cofactors and enzymic activities that modulate chromatin accessibility. We describe also the role and biochemical ...
متن کاملNUREBASE: database of nuclear hormone receptors
Nuclear hormone receptors are an abundant class of ligand activated transcriptional regulators, found in varying numbers in all animals. Based on our experience of managing the official nomenclature of nuclear receptors, we have developed NUREBASE, a database containing protein and DNA sequences, reviewed protein alignments and phylogenies, taxonomy and annotations for all nuclear receptors. Th...
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ژورنال
عنوان ژورنال: Cell
سال: 2002
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(02)00710-9